You know what would be a good idea? Get an unstable alcoholic star who won't be able to restrain himself and act like a decent person, film in a politically conservative region where cops won't put up with his crap, where he'll almost certainly end up in jail or on a chain gang and, when the inevitable happens and your production is ruined, collect a big insurance pay off.
I'm not sure there would be any point in this unless the insurance company would pay more than the amount invested to make the movie.
The producers of Peanut Butter Falcon should think about how they'll finish the movie if Shia LaBeouf is taken away. He plays a criminal who helps a young man with Down syndrome reach some sort of training camp to become a professional wrestler. They could have Shia taken away by police or drown in the river and have another character step in to complete the task.
This happened years ago to Larry Cohen. Bette Davis walked off the set of The Wicked Stepmother (1989) either due to problems with the script and how she was photographed or because of ill health. He had to scramble to rewrite the script. I thought the result was okay.